United in science: SLU’s role in unraveling genetic mechanisms of antimicrobial resistance in Escherichia coli amid Morocco’s climate change crisis

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This blog is written by Ikhlass El Berbri, associate professor of animal infectious diseases at the Agronomy and Veterinary Institute Hassan II, Morocco.

Ikhlass El Berbri and Erik Bongcam-Rudloff in Rabat, Morocco.

The world is currently facing an anthropogenic climate crisis that is already impacting human health and is likely to do so in increasingly severe ways. Climate change effects on human health include heat-related mortality, a variety of health issues from natural disasters like flooding and droughts, food insecurity due to reduced crop yields, and a heightened risk for the transmission of infectious diseases and the spread of antibiotic-resistant bacteria. Furthermore, climate-induced changes in temperature and rainfall, along with extreme weather events, promote the proliferation of resistant bacterial strains and increase the need for antibiotics, compounding the problem of antibiotic resistance.

The emergence of multiple drug-resistant bacteria is indeed rising to dangerously high levels globally, severely undermining the effectiveness of available antibiotics. As a result, even minor injuries and routine medical procedures now pose serious risks due to antibiotic-resistant infections.

Escherichia coli is a common pathogen found consistently in the digestive tracts of animals and humans, as well as in the environment. Multidrug resistance in Escherichia coli has become a concerning issue, increasingly observed in both humans and veterinary medicine worldwide. E. coli is intrinsically susceptible to almost all clinically relevant antimicrobial agents, but this bacterial species has a great capacity to accumulate resistance genes, mostly through horizontal gene transfer. In recent years, E. coli has become one of the common bacterial sources to antimicrobial resistance genes, which has been prevalent and exhibited an increasing trend. One of the most important factors favouring this spread is ecosystems and climate deregulation, which cause human and animal populations to migrate and create novel transmission pathways for pathogens, including E. coli.

In this context, and to assess the role of the environment in the transmission and spread of resistant bacteria, our project aims to determine the genetic relatedness of multidrug-resistant Escherichia coli isolated from animals and their environment.

With this regard, and to ensure that the results are thoroughly and effectively explored to understand the genetic mechanisms underlying this phenomenon, and in order to improve my skills in term of genomic sequencing and bioinformatics analysis, I have opted for a collaboration with a team with international renown researchers from the Department of Animal Sciences, Bioinformatics Section, led by Professor Erik Bongcam-Rudloff, at the Swedish University of Agricultural Sciences (SLU). The team’s innovative work and collaborative environment offer a unique chance to explore the complexities of my research, using their expertise to improve my understanding of the outcomes of my results.

      A photo capturing the essence of teamwork at the lab at SLU. Photo: Udeshika Sewwandi

During my stay at SLU, I gained a wealth of valuable knowledge and experience. I had the privilege of engaging with renowned experts in the field and built a strong network of contacts. These connections are very important for my academic journey and are also instrumental in facilitating future collaborations. Professor Erik Bongcam-Rudloff also visited the Veterinary Institute Hassan II in Morocco, where he delivered lectures and tutorials on bioinformatics for students and researchers. Following these productive exchanges of researchers between Sweden and Morocco, we are now prepared to launch new projects that leverage our combined expertise to address significant global health challenges.

 

Beyond university gates: How research makes big impact to society in Rwanda

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This blog post is written by Alin Kadfak, researcher at the Department of Rural and Urban Development (SLU), in connection with a visit to Sweden by researchers from the University of Rwanda. The blog post was first published at SIANI’s website.

Dr. Jennifer Batamuliza talking about how the University of Rwanda contributes to gender equality in Science, Technology, Engineering and Mathematics (STEM). Photo: SLU Global

Obliged to focus on teaching and engaging with busy research work, researchers often fail to think beyond academic results. Dr. Jennifer Batamuliza and Professor Alfred Bizoza from the University of Rwanda (UR) informed us about techniques for transferring university knowledge to real-world impacts. 

What bring you to Sweden?

We are here to continue planning our courses as part of our collaboration between SLU and the UR in one of the fifteen sub-programmes of Sida-funded bilateral capacity-building programmes. The Engendering Rural Transformation and Sustainable Development (ENTRUST) sub-programme has four PhD students, three of whom are studying at the Swedish University of Agricultural Sciences.  Since 2017, we have closely collaborated with the Department of Rural and Urban Development and the Department of Economics at SLU. While visiting Sweden, we are collaborating developing two doctoral courses to be integrated at the University of Rwanda. The first PhD course “Farming, food consumption and health”, is being co-designed with Associate Professor Linley Chiwona Karltun of SLU. This is a collaborative undertaking with Dr Franklin Amuakwa Mensah at LuleĂ„ University of Technology, where our fourth PhD candidate is based. The second course focuses on “Information Communication Technology, Gender and Rural Transformation”, and we are partnering closely with Associate Professor Caroline Wamala Larsson, based at SPIDER at Stockholm University. Both courses are planned to be run as pilots in May-June 2025 and will be open to PhD students globally, focusing on the African context.

 

Such true collaboration brings up many lessons from both partners. We have learnt great stories from your works that create real impact on society. Can you share some of those examples with us?

One concern is that gender inequality remains high in the higher learning education in Rwanda. As shown in figure 1, the number of teachers, both male and female, has dropped drastically after primary education. One-fourth of the lecturers at university level are female. There are a serious concern that many of the girls and women do not make it to the top to pursue a professional career.

Figure 1: Male and Female Teachers/ Lecturers at all levels of education in Rwanda (Statistical Year Book , MINEDUC,2023) 

Women and girls make up half of the world’s population and hold half of the world’s human potential. When their lives are improved, the benefits reverberate across society. Access to decent work and regular income in the hands of women, for example, contributes not only to poverty reduction (SDG 1) but also supports better education, health and nutrition outcomes for women and girls and those who depend on them (SDGs 2, 3 and 4).

Mainstreamed diversity and gender perspectives in law and established programmes on gender studies lead to structural changes in institutions to make equality possible. At UR, we have a unique programme that supports girls and women in pursuing their education in science to build a more inclusive and equitable career path in science and technology. This is because we believe that science-related fields play a crucial role in sustainable development and women’s potential for creation and innovation cannot be left behind. Professional education for women is one of the solutions.

Source: Dr. Jennifer Batamuliza

Source: Dr. Jennifer Batamuliza

So, it is time to rethink gender relations to science! What is the role of science, technology, engineering and mathematics in countering this challenge?

Yes! STEM is a learning approach that integrates the areas of Science, Technology, Engineering and Mathematics (STEM), and we hope to encourage more girls and women to participate in this programme at our university. As many of us know, STEM is a male-dominated space, and we are trying hard to stop the leaky pipeline of women within the STEM field and create more inclusive workplaces and ecosystems to retain and support women in their STEM career advancement. Gender inequality in STEM is a result of stereotypes, bias and inequality that limits girls’ expectations and professional goals.

In Rwanda, as in many parts of the world, women and girls continue to be subject to social and cultural restrictions. Limited access to education and unfavourable treatments in working environments may hamper women’s advancement. At present, only 32% of young women are entering STEM programmes in Rwanda due to issues such as social and cultural restrictions and societal structure, which need to be changed.

 

How to address gender inequality through STEM?

There are many things you can do, but here are some points where we have started to see changes.

  • Creating role models: at the University of Rwanda, there is the Association of Women in Science and Engineering (RAWISE). This group is self-initiated by many female faculty members who come together and mentor to other female students. Having such a platform creates more than a role model, where the students can see their near future potential, and it provides open and safe spaces to share opportunities and challenges.
  • Networking: we started a virtual regional platform that serves as a networking space for women in STEM and helps them share and make available training courses and digital materials. Our university celebrates the International Day of Women and Girls in Science every year.

Can you tell us more about your other outreach activities beyond university gate?

Through the ENTRUST programme, we initiated a Societal University Village Initiative (SUVI) model in 2019, piloted and tested by the UR in 2018. We select “SUVI champions”, graduate students paired with people in the communities, and develop project ideas focusing on rural development, poverty alleviation and food security to implement at village level. Our SUVI champions work with local people to solve the real problems concerning their livelihoods, using the students’ science and technology skills. Results and stories from implementing the model tell us that this model is scalable and impactful.

There are several success stories from SUVI champions. The prominent one is their ability to create their own business plans to address the challenges facing their communities. For instance, SUVI champions are helping small farmers establish kitchen gardens to address issues of malnutrition. Similarly, others have initiated their small businesses, such as livestock rearing (cows, goats, sheep, pig, rabbits) and farming-related activities, such as farming mushrooms and other crops, in collaboration with communities where they are deployed. The SUVI model helps students to create their own jobs after their service through SUVI instead of waiting three to five years before getting employed. This model makes the skills and competencies available for rural transformation and ensures the equity in knowledge distribution across the country rather than being concentrated in the cities.

Source : SUVI, 2023

Source: SUVI, 2019

Source: SUVI, 2019

Dr. Jennifer Batamuliza is a lecturer at the University of Rwanda and a head of Data Driven Incubation Hub and Short Professional Courses at African Center of Excellence in Data Science, University of Rwanda. She is also a founder of RWA TECH HUB an organization that trains and mentors girls in ICT.  

Prof. Alfred R. BIZOZA is a Professor of Agricultural Economics from the University of Rwanda (UR) with extensive academic and policy research experience in areas of Agricultural Economics, Institutional Economics of Soil and Water Conservation, Economics of Land, Economics of Climate Change Adaptation, and Economic perspectives of Gender. 

Associate Professor Linley Chiwona Karltun is a researcher at the Department of Urban & Rural Development, Rural Development division at SLU, and a co-lead investigator for the Sida-funded bilateral capacity building programmes Engendering Rural Transformation and Sustainable Development (ENTRUST) sub-programme.  

What’s cooking at CGIAR?

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Photo credit: UN Sustainable Development Goals

SLU has a long tradition of partnerships with the CGIAR, both at the institutional and individual scientist-level. The CGIAR is the world’s largest agricultural research and innovation network with 8 000 staff globally, focused on agriculture in low and middle income countries.

The CGIAR is currently reorganizing and has launched a new research and innovation strategy with the aim to transform food, land and water systems in a climate crisis. The One CGIAR vision for 2030 is a world with sustainable and resilient food, land and water systems that deliver diverse, healthy, safe, sufficient and affordable diets, and ensure improved livelihoods and greater social equality, within planetary and regional environmental boundaries. Climate change and the climate crisis is at the forefront of the new strategy that describes the food systems challenges in the contexts of six major regions across Africa, Latin America and the Caribbean, South Asia and Southeast Asia and the Pacific.

The strategy targets multiple Sustainable Development Goals (SDGs) and strives to achieve measurable benefits across five Impact Areas: (1) Nutrition, health and food security, (2) Poverty reduction, livelihoods and jobs, (3) Gender equality, youth and social inclusion, (4) Climate adaptation and mitigation, and (5) Environmental health and biodiversity. Three-year investment plans are set up for 2022-2024 and a number of CGIAR Initiatives (research programs) are under development. These initiatives will replace the previous Research Programs (CRPs).

The CGIAR will work with regional and national partners including universities and research institutes, business actors, and international partners. Scientists at SLU together with partners in low- and middle income countries from collaborations in research and capacity development are well positioned to contribute to this work. SLU’s global policy for Agenda 2030 points to several opportunities for cooperation between SLU and the CGIAR to contribute to the SDGs. To facilitate and support the dialogue between scientist at SLU and the CGIAR, a one page capacity statement based on SLU’s policy and the CGIAR strategy is made available here.

For more information, please contact the authors:
Ingrid Öborn, Professor at the Department of Crop Production Ecology, ingrid.oborn@slu.se
Ulf Magnusson, Professor at the Department of Clinical Sciences’, ulf.magnusson@slu.se
Sara GrÀslund, Head of SLU Global, sara.graslund@slu.se

Why do we collaborate?

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The next chapter of SLU – Vietnam collaborations

Photo: Agnes Bondesson, SLU

Looking back

More than 35 years ago, the Swedish University of Agricultural Sciences’ (SLU) initiated contact with Vietnamese universities with support from Sida/SAREC. The early research capacity development programmes aimed to strengthen individual and institutional research capacity in Vietnamese priority areas. The programmes have been part of the development agenda to reduce poverty and contribute to the socio-economic development of Vietnam. Several departments and faculties at SLU have over the years been involved in the collaborations. Some of these projects have also involved Swedish MSc and PhD students who have been able to conduct fieldwork in Vietnam. Many programmes have been large long-term projects involving several universities and research institutes in Vietnam and resulting in a large number of Vietnamese MSc and PhD graduates.

SLU Global conducted a detailed evaluation report to increase learning from experiences and to feed into our present and future international collaborations. Focus of the evaluation was on initiatives within the sectors relevant to agriculture, rural development, and forestry. The time scope for the study was 1977-2018. Collaborations result in both long-listed research projects and education. Both key activities provided capacity development at institutional level/national level as well as individuals, and Vietnamese society.

Looking forward into future

1 October 2020, SLU global opened up a new chapter of collaborations by inviting SLU and Vietnamese researchers to an online workshop aiming to be a discussion forum for researchers, teachers and others to explore opportunities and interest in future collaborations based on past experiences between SLU and Vietnam. The purpose with this workshop was to create new possible networks and exchange knowledge between researchers, teachers and others at SLU and in Vietnam. More than 55 researchers were participating in small group discussions to potential future collaborations and what tools we need to make the collaborations possible. Tools, as we recognised from our experiences were not only required research competent, but also administrative supports from the universities. SLU and Uppsala University has joint representative office in Hanoi, providing supportive services connecting researchers and students, including alumni, between the two countries. Moreover, the workshop also made visible financial opportunities from Vietnam, Sweden and the EU.

A small but important step to the future is to allow researchers/teachers between the two countries to discuss their common interests as well as challenges. During the workshop, researchers were divided into 8 groups according to research interests. Common topics discussed during this workshop are varies including, land transformation, climate change, transformation from rice to horticulture, small scale forestry, pest control, agri-business, remote sensing in forest research, payment for forest environmental forestry scheme (PES), animal health, agroforestry etc. Moreover, the workshop group discussions continued to discuss the Joint teacher student exchanges and the access to new online courses. One concrete example is the course on bioinformatics, which is being developed to be given fully digitally by SLU. Voicing from the discussion, researchers from both countries would like to see the expansion of the collaboration beyond Sweden-Vietnam, but South East Asia as target region.

One of the main challenges to continue the engagement is the limitation of funding, considering Vietnam is no longer a priority for international development. Researchers can overcome this challenge by searching new financial opportunities, such as EU and the private sector, as well as focusing on early career development for researchers from low and low-middle income countries. Decreasing of financial support does not stop the ‘Will to Collaborate’. With Covid-19 in the background, online communication channels and platforms will continue to increase, which benefits a long term conversation between researchers and teachers between the two countries.

This blog post was written by Alin Kadfak, Communications Coordinator, SIANI