Monthly Archives: March 2020

How can we avoid another virus outbreak?

By: Maja Malmberg, Researcher at the Section of Virology at the Department of Biomedical Sciences and Veterinary Public Health at SLU and Ekaterina Bessonova, Communications Officer at SIANI. This blog was originally posted at SIANI website

Photo: Peter Schaefer (EyeEm) / Getty Images.

Few of us have ever imagined living through a pandemic. With all the global progress and achievements in medicine, a contagion seemed like something from the dark ages. And here we are, battling a noxious virus that set foot in every country, bringing disease, disruption and dismay.

Covid-19 outbreak is still unfolding, and we are yet to fully experience its effect on our societies and lives. However, it’s worth looking into how this coronavirus came about and reflecting on what can be done to diminish the possibility of another pandemic.

How did Covid-19 emerge?

SARS-CoV-2 or Severe Acute Respiratory Syndrome Coronavirus 2, the virus that causes Covid-19, is most closely related to coronaviruses in bats, meaning it’s a zoonosis – a disease that pass from an animal or insect to a human.

Other examples of zoonotic diseases include such scary names as HIV, Zika and Ebola. But Covid-19 belongs to the same family of coronaviruses as SARS and MERS.

The outbreak of SARS in 2002 resulted in 8,098 cases and 774 deaths in 26 countries. Emerging in Saudi Arabia in 2012, MERS brought about 2,494 cases and 858 deaths in 27 countries. Both of them are thought to be bat viruses that got to humans through an intermediate host (civet cat and camel).

Comparing to its “family members”, SARS-CoV-2 has certainly been more effective in infecting humans – the number of reported cases has already passed over 400 000 and rising. The virus was only discovered in January 2020 and much more research is needed to fully understand it. Nevertheless, there are things we already know.

Thanks to its structure, which is essentially a spiky ball, the virus easily attaches to the surface of certain human cells, initiating infection. Unlike most of the respiratory viruses that infect either upper or lower airways, SARS-Cov-2 seems to infect both. Generally, upper-respiratory infections are easily transmitted and usually mild; lower-respiratory infections don’t spread as easily but are more severe. Additionally, the new coronavirus can be stable on surfaces for as long as 24 hours, which along with the fact that humans do not have immunity against it, facilitated such rapid spread around the world.

Exactly when and how the virus has first infected humans remains to be determined. It could have come from bats to humans directly or passed through another animal. Coronaviruses are famous for their ability to exchange part of its genome, the so-called recombination, something that makes them prone to change hosts.

Covid-19 is believed to originate from a wildlife market in Wuhan, China where alive wild animals were sold and butchered on the spot, usually using the same slaughtering tools for different species, which creates favorable conditions for the virus to jump from animals to humans. Such markets are a perfect melting pot for new viruses to emerge and spread. However, there are reports of early cases of Covid-19 in people with no links to the market, suggesting the initial point of infection may have been in a different place.

Photo: Ulet Ifansasti (Stringer) / Getty Images

Biodiversity, biosafety, bioinformatics: A virus risk management strategy

Prompt by the ongoing epidemic, China announced a permanent ban on wildlife trade and consumption. The global community greeted this measure as a major step, though the ban has already been criticized because it allows the trade of animals for fur, medicinal purposes and research. Additionally, China announced a similar ban in 2002 in connection to the SARS outbreak, but enforcement was relaxed after the epidemic was over and the trade rebounded.

Banning trade of wild animals is a straightforward measure to limit exposure to new pathogens. However, it is not the only reason behind the Covid-19 outbreak. Diminishing the emergence of new zoonotic diseases requires holistic strategies that reduce risks across several dimensions and make our societies more resilient to virus outbreaks.

First, all development strategies and activities must prioritize biodiversity and find a way to create jobs, generate incomes and increase wellbeing, without destroying nature.

The emergence of new pathogens tends to happen in places where a dense population has been changing the landscape – agricultural expansion, deforestation, construction, mining – all contribute to the loss of natural habitat. So, the area occupied by human activity is becoming larger, while wild animals are squeezed into shrinking spaces. That is why animals that wouldn’t normally come in contact with humans do so to a higher extent, increasing the risk for exposure and spread of viruses wild animals carry and that we have not experienced before.

For instance, recent research from the Swedish University of Agricultural Sciences (SLU) indicates that large forest fires can increase the spread of rodent-borne diseases in Sweden. However, the risks of emerging zoonotic diseases are especially high in the forested tropical regions experiencing rapid land-use changes and with high wildlife biodiversity.

Second, livestock industry and farmers have to implement adequate biosafety measures

Covid-19 sparked discussion about whether animal-based diets play a role in the emergence and spread of unknown and dangerous viruses. While there is plenty of research pointing that moderate consumption of meat has strong health and climate benefits, to what extent livestock production represents a risk of emergence of zoonosis depends on production management factors and country context.

For instance, small scale organic livestock farming is based on the principle that animals roam close to natural forests. This method is praised for animal wellbeing and lower environmental impact, but it makes contact between domestic animals and wildlife more likely. At the same time, industrial farms would usually keep animals isolated, creating conditions that prevent the spread of diseases from wild animals, however, because the animals are kept so densely to each other, diseases spread fast within the herd. Furthermore, plant-based diets that utilize a lot of commodities like almonds, soy, avocadoes and cocoa aren’t necessarily deforestation-free.

Another key point to consider is that vegan diets may not be the best option for people in low-income countries with high malnutrition. Milk, eggs and meat are highly nutritious, so many people keep animals at home for food and for insurance in times of need. There are also traditional pastoralist communities who live in drylands. For them animal husbandry is not only a source of food security, but also the core of culture.

For these reasons, increasing biosafety standards may offer a more appropriate way to reduce the risk of zoonotic diseases than excluding animal-based foods. Some common measures include keeping animals outside of the house, introducing designated areas for slaughtering and ensuring these facilities and people who work there practice well-executed hygiene and sanitation of all processes and equipment.

Third, funders need to ramp up investment in virology and bioinformatics, while the international community needs to improve cooperation, increase local capacities and raise awareness about these fields of knowledge.

The risk that new viruses can emerge and spread will always be there. But it is possible to minimize the losses by means of fast accurate detection and early response. Mapping the existing viruses in all animals will help us know what is out there and start developing technologies and strategies that can help us prepare and cope with possible outbreaks, pivoting from reactive to a proactive response. Advancing bioinformatics and virology will not only help us develop vaccines, but also anticipate pandemics through monitoring of threats while they are still evolving in animal populations.

Raising general awareness about what viruses are, how they spread and how one can protect from them is also key. Knowledge can conquer panic and prevent the creation and spread of conspiracy theories and fake news.

Tanzanian-Swedish collaboration at the World Urban Forum 2020

By: Edson Sanga, Happiness Mlula, Lazaro Mngumi, Maglan Sang’enoi and Said Nuhu.
PhD candidates at SLU enrolled in the Capacity Building Research Training Partnership with Ardhi University in Tanzania.

On 8-14 February, the tenth session of the World Urban Forum (WUF 10) was held in Abu Dhabi, United Arab Emirates (UAE). This year SLU arranged two side events presenting research results in the field of sustainable urban development, and participated with an exhibition stand at the Urban Expo. A group of five SLU PhD candidates, enrolled within the Capacity Building Research Training Partnership with Ardhi University in Tanzania, participated in the forum together with their supervisor Zeinab Tag-Eldeen, researcher at the Department of Urban and Rural Development.

From left: Maglan Sang’enoi, Said Nuhu, Zeinab Tag-Eldeen, Lazaro Mngumi, Happiness Mlula and Edson Sanga; Photo: Anna Villaplana Casaponsa

The overriding theme of the WUF10 was Cities of Opportunities: Connecting Culture and Innovations. As part of the global pathways for realising the Sustainable Development Goals (SDGs), UN-Habitat convene this forum for sharing information, best practices, discussing emerging issues and possible options. SLU participated in the forum, by sharing research grounded innovative ideas relating to rural and urban development. SLU participated under the sub-theme Sparking Research into Global Transformation which has a niche on theorising and practicing planning and decision analysis in different national and international contexts.

PhD candidates respond to questions related to their projects during one of the side events. Photo: Anna Villaplana Casaponsa

Side events

The SLU team convened two side events where we presented our research results; Side event 38: Urban-rural nexus: challenges and innovations to govern land, municipal and ecosystem services, on the fringes of resources constrained cities and small town and Side event 36: Beyond informality: informal settlements as contemporaneous urban heritage. The aim was to discuss new and innovative solutions of the dynamic shifts of activities that contribute to the well-being of rural as well as urban survival, particularly in the transforming areas of rural Africa. Topics that came up during the discussions were for example food security matters in relation to rural and urban interactions; informality, land governance and climate change in developing countries context.; and how to take research results and recommendations into practice.

The Urban Expo

The Urban Expo promoted innovative and sustainable solutions to the challenges facing cities and communities, including perspectives from national governments, the private sector, international organisations and academia. SLU’s exhibition stand highlighted how to strengthen social cohesion, exchange cross-disciplinary perspectives and link arts to sustainable development. Our booth received many visitors from both the academia and practice (both national and international organisations) with varying interests related to SLU’s global agenda. Academic matters offered by SLU, in particularly degree programmes, respective teaching language(s), preliminary conditions for enrolment as well as how to get scholarships, were some of the general issues that visitors wanted to know about. More specifically visitors asked about the role of SLU in conducting agriculture in hot climates like desert areas; food security related matters and SLU’s research agenda towards this topic; SLU research collaboration with UAE countries; and opportunities for collaboration with universities from some institutions in low-income countries.

Hon. William Lukuvi, the Minister of Land, Housing and Human Settlements Development of Tanzania visited SLU’s exhibition stand. From left: Zeinab Tag-Eldeen, Happiness Mlula, Hon. William Lukuvi, Said Nuhu. Photo: Anna Villaplana Casaponsa

Hon. William Lukuvi, the Minister of Land, Housing and Human Settlements Development of the United Republic of Tanzania, visited our stand, and got information about our five PhD projects conducted in Tanzania with the collaboration of between SLU and Ardhi University. The minister in his remarks emphasised that it is important to put the research into practices, and in this case this can be achieved through cooperation with the Local Government Authorities (LGAs) in Tanzania. 

Outcomes and take-home messages

By taking part in this conference we have established networks with people from various agencies, universities and organisations from across the globe. As the forum congregated people from all over the world with different exposure and ways of doing things, we have got experience from preparation of world class exhibition materials, art of presentation as well as confidence.

We think that participation in such international forum is imperative for the university’s internationalisation as it exposes the work done at the university and thereby attract new collaboration pathways. Networking and advertising SLU in matter related to land governance, climate change and rural-urban linkage can be done in this kind of forum.  

Background information

The World Urban Forum is organised and convened by UN-Habitat and addresses one of the most pressing issues facing the world today: rapid urbanisation and its impact on communities, cities, economies, climate change and policies. SLU’s participation was supported by SLU Global and led by Zeinab Tag-Eldeen, Researcher at the Department of Urban and Rural Development, and coordinator of the Research Platform Sparking Research into Global Transformation.

Capacity Building Research Training Partnership with Ardhi University in Tanzania
Within this programme, funded by Sida 2015-2020, several research projects are carried out in collaboration between the Urban and Rural Development Department at SLU, and Ardhi University.