This article was written by Susanna Sternberg Lewerin, Professor in Epizootiology & Disease Control at the Department do Biomedical Sciences & Veterinary public Health, SLU.
Antibiotics kill susceptible bacteria while those who have acquired traits to destroy the drug or protect themselves from it survive and multiply. Resistant bacteria can share their resistance genes with others. Illustration: SLU
Today is the Antibiotic Awareness Day. It is a day to be grateful for these important medicines, and to consider how to best preserve them for the future.
Antibiotics, drugs to combat bacteria, are useful tools in both veterinary and human medicine. They allow us to treat bacterial infections in animals and people, common diseases as well as those that occur due to immunosuppressive treatments such as cancer therapy or following transplant surgery. The problem is that all use of antibiotics kills the susceptible bacteria and leave the field open for those who have become resistant to the antibiotic. In a successful treatment course, the few remaining (resistant) bacteria can be killed by the host’s immune system and the host, animal or person, is cured. On the other hand, if the majority of the disease-causing bacteria are resistant, the treatment will be ineffective.
To preserve antibiotics as medical tools, we must use them as little as possible, only when needed, in the correct dose so that enough of the drug reaches the body site where the bacteria are causing the disease, and only for the time needed, until the immune system has eliminated the disease-causing bacteria. This is not as easy as it sounds, it takes insight into what diseases cause problems in animals and people in different settings, how to prevent them and how to treat them effectively, with or without antibiotics.
In Sweden, disease prevention is a key feature of veterinary medicine. Good animal husbandry, good biosecurity, vaccination and other strategies to control and prevent disease has been and continues to be a major research focus. We also collaborate in EU projects where different practices, attitudes and societal systems present new challenges that can be addressed by learning from the Swedish experiences (successes as well as failures) and by new ideas and innovations.
In low-income countries, antibiotics are not restricted to prescription from a veterinarian or a doctor but can be bought over-the-counter in drug stores where the products can be of poor quality and the information about how to use them may be lacking or misleading.
Poor farmers sometimes use the volume intended for treatment of one animal to treat several animals (i.e. with a lower dose), rendering the treatment ineffective and paving the way for resistant bacteria without curing the disease. If no veterinarian is involved in determining the cause of the disease, antibiotics may be used to treat diseases that are not caused by bacteria, so that the treatment is a waste of money and, again, promotes the resistant bacteria.
We collaborate with researchers in low-income countries on how to prevent and control animal diseases. We also work on developing systems for monitoring of diseases and antibiotic use, to provide information about what diseases are common and which antibiotics are used effectively. This project also addresses ways to increase the interaction between veterinarians and farmers by video consultations, to facilitate farmers’ access to veterinary advice on disease treatments while improving profitability for both groups.
It is important to recognise the need for different strategies in different settings, disease prevention and control rely on knowledge of the local situation and its context-specific challenges and opportunities. Still, the worries and hopes of farmers are similar in countries all over the world and serve as incentives for improvement of animal health and production. The long-term goals of our research focus on animal health and welfare, for a sustainable animal production with a sustainable use of antibiotics. We must all contribute to preserving antibiotics for the future. Don’t let it be nobody’s responsibility, it lies with everyone.
By: Maja Malmberg, Researcher at the Section of Virology at the Department of Biomedical Sciences and Veterinary Public Health at SLU and Ekaterina Bessonova, Communications Officer at SIANI. This blog was originally posted at SIANI website
Few of us have ever imagined living through a pandemic. With all the global progress and achievements in medicine, a contagion seemed like something from the dark ages. And here we are, battling a noxious virus that set foot in every country, bringing disease, disruption and dismay.
Covid-19 outbreak is still unfolding, and we are yet to fully experience its effect on our societies and lives. However, it’s worth looking into how this coronavirus came about and reflecting on what can be done to diminish the possibility of another pandemic.
How did Covid-19 emerge?
SARS-CoV-2 or Severe Acute Respiratory Syndrome Coronavirus 2, the virus that causes Covid-19, is most closely related to coronaviruses in bats, meaning it’s a zoonosis – a disease that pass from an animal or insect to a human.
Other examples of zoonotic diseases include such scary names as HIV, Zika and Ebola. But Covid-19 belongs to the same family of coronaviruses as SARS and MERS.
The outbreak of SARS in 2002 resulted in 8,098 cases and 774 deaths in 26 countries. Emerging in Saudi Arabia in 2012, MERS brought about 2,494 cases and 858 deaths in 27 countries. Both of them are thought to be bat viruses that got to humans through an intermediate host (civet cat and camel).
Comparing to its “family members”, SARS-CoV-2 has certainly been more effective in infecting humans – the number of reported cases has already passed over 400 000 and rising. The virus was only discovered in January 2020 and much more research is needed to fully understand it. Nevertheless, there are things we already know.
Thanks to its structure, which is essentially a spiky ball, the virus easily attaches to the surface of certain human cells, initiating infection. Unlike most of the respiratory viruses that infect either upper or lower airways, SARS-Cov-2 seems to infect both. Generally, upper-respiratory infections are easily transmitted and usually mild; lower-respiratory infections don’t spread as easily but are more severe. Additionally, the new coronavirus can be stable on surfaces for as long as 24hours, which along with the fact that humans do not have immunity against it, facilitated such rapid spread around the world.
Exactly when and how the virus has first infected humans remains to be determined. It could have come from bats to humans directly or passed through another animal. Coronaviruses are famous for their ability to exchange part of its genome, the so-called recombination, something that makes them prone to change hosts.
Covid-19 is believed to originate from a wildlife market in Wuhan, China where alive wild animals were sold and butchered on the spot, usually using the same slaughtering tools for different species, which creates favorable conditions for the virus to jump from animals to humans. Such markets are a perfect melting pot for new viruses to emerge and spread. However, there are reports of early cases of Covid-19 in people with no links to the market, suggesting the initial point of infection may have been in a different place.
Biodiversity, biosafety, bioinformatics: A virus risk management strategy
Prompt by the ongoing epidemic, China announced a permanent ban on wildlife trade and consumption. The global community greeted this measure as a major step, though the ban has already been criticized because it allows the trade of animals for fur, medicinal purposes and research. Additionally, China announced a similar ban in 2002 in connection to the SARS outbreak, but enforcement was relaxed after the epidemic was over and the trade rebounded.
Banning trade of wild animals is a straightforward measure to limit exposure to new pathogens. However, it is not the only reason behind the Covid-19 outbreak. Diminishing the emergence of new zoonotic diseases requires holistic strategies that reduce risks across several dimensions and make our societies more resilient to virus outbreaks.
First, all development strategies and activities must prioritize biodiversity and find a way to create jobs, generate incomes and increase wellbeing, without destroying nature.
The emergence of new pathogens tends to happen in places where a dense population has been changing the landscape – agricultural expansion, deforestation, construction, mining – all contribute to the loss of natural habitat. So, the area occupied by human activity is becoming larger, while wild animals are squeezed into shrinking spaces. That is why animals that wouldn’t normally come in contact with humans do so to a higher extent, increasing the risk for exposure and spread of viruses wild animals carry and that we have not experienced before.
For instance, recent research from the Swedish University of Agricultural Sciences (SLU) indicates that large forest fires can increase the spread of rodent-borne diseases in Sweden. However, the risks of emerging zoonotic diseases are especially high in the forested tropical regions experiencing rapid land-use changes and with high wildlife biodiversity.
Second, livestock industry and farmers have to implement adequate biosafety measures
Covid-19 sparked discussion about whether animal-based diets play a role in the emergence and spread of unknown and dangerous viruses. While there is plenty of research pointing that moderate consumption of meat has strong health and climate benefits, to what extent livestock production represents a risk of emergence of zoonosis depends on production management factors and country context.
For instance, small scale organic livestock farming is based on the principle that animals roam close to natural forests. This method is praised for animal wellbeing and lower environmental impact, but it makes contact between domestic animals and wildlife more likely. At the same time, industrial farms would usually keep animals isolated, creating conditions that prevent the spread of diseases from wild animals, however, because the animals are kept so densely to each other, diseases spread fast within the herd. Furthermore, plant-based diets that utilize a lot of commodities like almonds, soy, avocadoes and cocoa aren’t necessarily deforestation-free.
Another key point to consider is that vegan diets may not be the best option for people in low-income countries with high malnutrition. Milk, eggs and meat are highly nutritious, so many people keep animals at home for food and for insurance in times of need. There are also traditional pastoralist communities who live in drylands. For them animal husbandry is not only a source of food security, but also the core of culture.
For these reasons, increasing biosafety standards may offer a more appropriate way to reduce the risk of zoonotic diseases than excluding animal-based foods. Some common measures include keeping animals outside of the house, introducing designated areas for slaughtering and ensuring these facilities and people who work there practice well-executed hygiene and sanitation of all processes and equipment.
Third, funders need to ramp up investment in virology and bioinformatics, while the international community needs to improve cooperation, increase local capacities and raise awareness about these fields of knowledge.
The risk that new viruses can emerge and spread will always be there. But it is possible to minimize the losses by means of fast accurate detection and early response. Mapping the existing viruses in all animals will help us know what is out there and start developing technologies and strategies that can help us prepare and cope with possible outbreaks, pivoting from reactive to a proactive response. Advancing bioinformatics and virology will not only help us develop vaccines, but also anticipate pandemics through monitoring of threats while they are still evolving in animal populations.
Raising general awareness about what viruses are, how they spread and how one can protect from them is also key. Knowledge can conquer panic and prevent the creation and spread of conspiracy theories and fake news.
